Serratiopeptidase, also known as Serrapeptase, is a proteolytic enzyme produced by submerged fermentation of Serratia marcescens. It is a zinc-dependent metalloprotease that specifically hydrolyzes non-living protein substances such as fibrin, inflammatory exudates, and necrotic tissues, while showing minimal effect on healthy living tissues.
Serratiopeptidase is widely used for its anti-inflammatory, anti-edema, fibrinolytic, and mucolytic activities. It helps reduce swelling and pain by degrading inflammatory mediators and fibrin deposits, promotes tissue recovery, and improves microcirculation.
Due to its ability to reduce mucus viscosity and enhance the penetration of antibiotics into inflamed tissues, Serratiopeptidase is commonly used in dietary supplements and pharmaceutical formulations for respiratory health, post-operative recovery, and inflammation management.
PRODUCT CHARACTERISTICS:
1. Temperature range: 20°C ~ 60°C Optimum Temperature: 45°C ~ 50°C
2. pH range: Effective pH 6.0 ~ 10.0 Optimum pH: ~9.0
3. Appearance: White to off-white powder
4. Enzyme activity: 20,000 IU/g, 40,000 IU/g, 100,000 IU/g (customized activity available)
5. Standard: JP (Japanese Pharmacopoeia), EP (European Pharmacopoeia), GB/T 1886.174-2016 (enzymes for food industry)
6. Enzyme activity definition: One Serratiopeptidase Unit (IU) is defined as the amount of enzyme that liberates peptides equivalent to 1 μg of tyrosine per minute from casein under specified assay conditions.
7. Effects of metal ions on enzyme activity: Serratiopeptidase is a zinc-dependent metalloprotease. Zn²⁺ is essential for catalytic activity. Ca²⁺ significantly enhances enzyme stability. Mg²⁺ shows variable or negligible effects depending on concentration. EDTA and heavy metal ions such as Ag⁺ and Hg²⁺ strongly inhibit enzyme activity.
APPLICATION:
The Serratiopeptidase produced by Serratia marcescens exhibits high proteolytic activity under alkaline conditions, with optimal performance around pH 9.0, making it particularly effective in hydrolyzing non-living protein substances such as fibrin, inflammatory exudates, and viscous mucus in the human body.
It is commonly used in enteric-coated tablets or capsules for nutraceutical and pharmaceutical applications, where it serves as a systemic enzyme to support inflammation management, reduce edema, and promote the absorption of inflammatory debris without affecting healthy tissues.
Serratiopeptidase can also be applied in formulations for respiratory health to reduce mucus viscosity and improve sputum clearance, as well as in post-operative or post-traumatic recovery products to enhance tissue healing and improve microcirculation.
PACKAGING: 20KG/drum, 25KG/drum
STORAGE AND SHELF LIFE: Serratiopeptidase has a shelf life of 2 years when stored in a cool, dry place away from direct sunlight. Refrigerated storage is recommended to maintain optimal enzyme activity.
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